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Gene Causing Breast Cancer In Nigerian Women Identified

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A multinational research team has identified the genes responsible for inherited breast cancer in Nigerian women, according to the study published in the August 21, 2018 issue of the Journal for Clinical Oncology.

“This is the first study to use high-throughput genomic analysis of African women,” said study author Olufunmilayo Olopade, MD, Walter L. Palmer, Distinguished Service Professor of Medicine and Human Genetics and Director of the Center for Clinical Cancer Genetics and Associate Dean for Global Health at the University of Chicago.

“Based on state-of-the-art genomic technologies, two things were clear,” added co-author Mary-Claire King, PhD, American Cancer Society Professor of Medicine and Genome Sciences at the University of Washington in Seattle. “Risks to Nigerian women who carry mutations in breast cancer genes are higher than risks to women in the U.S. with mutations in the same genes. And inherited breast cancer plays a bigger role in the total occurrence of breast cancer in Nigeria compared to the U.S.”

According to a report by www.news-medical.net, the study enrolled 1,136 women with invasive breast cancer and 997 controls, women of similar ages and heritage who did not have breast cancer.

The disease was far more advanced at diagnosis than in the US, with 86 per cent of the patients who were fully evaluated diagnosed at either stage 3 or stage 4.

Almost half (46 per cent) of the patients were diagnosed with triple-negative breast cancer (tumours that lack estrogen receptors, progesterone receptors and human epidermal growth factor receptors).

This is an aggressive breast cancer subtype, likely to have a poor prognosis, even in wealthy countries.

For their study of “Inherited Breast Cancer in Nigerian Women,” the authors sequenced 25 genes associated with increased risk of breast cancer and identified all damaging mutations in each of those genes.

They found that one out of eight breast cancers in the study was caused by an inherited mutation in one of four of these genes.

Mutations in BRCA1 (7 per cent of patients) and BRCA2 (4 per cent) were the most common, followed by PALB2 (1 per cent) and TP53 (0.4 per cent).

Patients with BRCA1 or TP53 mutations were diagnosed at younger ages than women with other mutations.

The mean age at diagnosis for all cases in the study was 47.5 years, but the BRCA1 carriers were diagnosed at an average age of 42.6 years.

Patients with TP53 mutations were diagnosed even earlier, at an average age of 32.8 years.

“Genomic sequencing to identify women at extremely high risk of breast cancer could be a highly innovative approach to tailored risk management and life-saving interventions,” the authors wrote. Given the limited treatment resources available in this setting, “prevention and early detection services should target these highest-risk women.”

Following up on the study, the Chicago-Ibadan team has already developed a risk-prediction model for breast cancer in Nigeria and other Sub-Saharan African women, who are, on average, more than 10 years younger when diagnosed than American women.

This predictive model can identify individuals at high risk of breast cancer, tailor surveillance and suggest risk-reduction strategies.

There is an urgent need to address “widening global disparities in breast cancer mortality that disproportionately impact women of African ancestry,” the authors wrote.

Breast cancer among both African American and Nigerian women is more frequently triple-negative than in other populations for complex reasons that remain poorly understood.

Given the young ages at diagnosis in Nigeria, focusing on genetically high-risk women could, the authors suggest “substantially reduce premature mortality from breast cancer.”

“It may seem paradoxical to apply the most recent technology in severely resource-limited settings,” the authors add, “but in fact, the solution fits the problem… Women with an extremely high risk of breast cancer due to mutations in these genes can be identified inexpensively and unambiguously, and offered interventions to reduce cancer risk.”

“Coordinating our team of clinicians and scientists and community elders in Nigeria was no small feat, but we got the job done despite resource constraints,” said Adeyinka Falusi, PhD Professor of Hematology and L’OREAL/UNESCO Laureate, Institute for Advanced Medical Research and Training in the College of Medicine, University of Ibadan.

“As the premier institution in Nigeria, the University of Ibadan remains committed to deploying science and technology to improve the health of Africans on the continent and throughout the diaspora,” Falusi said. “Lessons learned in Nigeria can be transferred back to low resource settings in the US and other countries.

African and African American women are more likely than women of other ancestries to develop and to die from triple-negative breast cancer.

The Nigerian Breast Cancer Study, based in Ibadan, South West Nigeria, has been in the field for more than 20 years.

During this period, breast cancer incidence throughout the country has steadily increased.

BIG STORY

Aare Adetola Emmanuelking Shines Bright As The Remo Day “Man Of Steeze” [PHOTOS]

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The Gateway Stadium, Sagamu was aglow yesterday, the 27th of December, 2024, as the maiden edition of Remo Day culminated in a grand rally celebrating the unity, culture, and progress of Remoland. Hosted by the revered Akarigbo of Remoland, the event brought together dignitaries from across the nation, including the Chief of Staff to the President of Nigeria, Hon Femi Gbajabiamila, the esteemed Governor of Ogun State, Prince Dapo Abiodun (MFR) and the first lady of the state, The Ewusi of Makun, HRH Oba Timothy Oyesola Akinsanya, ORUNAGBA II, Chairman of Adron Group and Otun Akile of Remoland Aare Adetola Emmanuelking, amongst others.

Aare Adetola Emmanuelking’s presence stood out in class as he brought unparalleled style, sophistication, and charm to the occasion. Dubbed the ” Remo Day Man of Steeze,” Aare Adetola made an unforgettable entrance, draped in an exquisite wine agbada adorned with intricate embroidery, accessorized with traditional coral beads, and crowned with a regal fila. His look, a masterclass in cultural elegance, radiated confidence and pride in Yoruba heritage, instantly earning him admiration from the gathered audience. Known for his charisma and commitment to the development of Remoland, Aare Adetola was the epitome of poise and grandeur as he engaged with other top dignitaries and attendees. From his interactions to his overall demeanor, every aspect of his presence reflected a deep connection to his roots, and an unyielding passion for community growth.

Communities from across Remoland including Epe, Makun, Iperu, Irolu, Emuren, Ogere, Ikenne, Ilara, Ode remo, Isara, Ipara, Ilishan, Soyindo, Ijagba, Ado, Ode lemo, Ibido, Idena, Ogijo, Atayo, Eposo, Idado, Latawa, Oko, Ipoji, Lowa ibu, Igbepa, Ijoku, Iraye, Ilupeju, Iraniken, Okeselu, Simawa, Ilaye, Iraye, Agura, Igode, Sotubo, Ariye , Araromi, Imushin, Imeji, Agbehinsa , and many more, converged at the Gateway Stadium to pay homage to the Akarigbo of Remoland, a revered symbol of unity and cultural pride. This act of respect and solidarity emphasized the deep-rooted connection between the people and their traditional ruler as they celebrated the remarkable growth and development of Remo. Among the many groups, Iyaniwura Base stood out under the distinguished leadership of Aare Adetola Emmanuelking. Following in his illustrious footsteps, the group brought a splash of vibrance to the event, dazzling attendees with their matching cultural attires that reflected the rich traditions of Remoland. Their coordinated elegance and enthusiastic homage added a memorable touch to the grand celebration.

The Remo Day celebration, themed “In Unity & Culture, We Thrive,” was more than a cultural showcase. It was a celebration of the strength and progress of Remoland, featuring colorful displays of traditional dance, drumming, and artwork. Amid the festivity, Aare Adetola’s magnetic personality and gallant appearance was a true highlight of the day. The Grand Rally provided a perfect backdrop for celebrating individuals who embody the spirit of Remo’s advancement. In Aare Adetola Emmanuelking, Remo found a true cultural icon, someone who not only lives the values of the community, but also inspires others to embrace and promote its legacy with pride and dignity.

The Remo Day celebrations may have concluded, but the image of Aare Adetola, standing tall in his resplendent attire, remains etched in the memories of attendees. Aare Adetola Olaonipekun Emmanuelking- a name synonymous with grace, culture, and unshakable pride in Remoland’s illustrious heritage. Indeed, the “Remo Day Man of Steeze” has set a standard that will resonate far beyond Remoland.

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BIG STORY

“My NGO Account Has Been Hacked, N160Million Diverted” — VeryDarkMan

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Popular activist and social critic, VeryDarkMan, has raised concerns about the hacking of his NGO account, which led to the diversion of N160 million.

In a video shared on his verified Instagram account on Friday, he revealed that the incident had left him feeling distressed in recent days.

He explained that the funds were stolen after hackers allegedly gained access to the NGO’s website. The compromised account, which initially contained N180 million, now holds only N20 million.

He mentioned that law enforcement agencies had tracked one of the suspects, resulting in an arrest.

To address the situation, he stated that the NGO’s app had been temporarily taken offline for maintenance to prevent further vulnerabilities.

He said, “For the past few days, I’ve not been myself. I am here with Officer Joe, and we are going to Jos. NGO money—somebody stole the money. Somebody hacked into the NGO website, and I don’t know how they did it. N180 million is missing, but thank God we have tracked the person, and we are on our way to Jos.

“They have arrested one person, and that is why I’m even saying it now. I’m excited, and the account has been put on PND. The account now has N20 million, while N160 million has been diverted to another account. We are currently going there to see how we can get the money back. I just want to update you people.

“I even had to shut down the app and put it on maintenance so that people will not really see what is going on, but let me just come out plain and tell everyone what is going on. Hopefully, we will get the money back.”

The NGO, which launched in October, gained significant attention after raising over N21 million within 24 hours of its inception.

The initiative, aimed at transforming Nigeria’s public education system, attracted support from prominent figures, including music producer Don Jazzy.

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Christmas Celebrations: Police Arrest 23 Suspected Armed Robbers, Hoodlums, Kidnapper, Recover Dangerous Weapons [PHOTOS]

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  • As IGP Commends Officers For Vigilance, Commitment To Safety

 

In furtherance of the directive of the Inspector-General of Police, IGP Kayode Adeolu Egbetokun, Ph.D., NPM., to commands and formations to emplace unalloyed anti crime strategies towards ensuring adequate safety and security during this festive period, operatives of the Nigeria Police Force across several states in the country have successfully apprehended multiple groups of armed robbers, cultists and hoodlums targeting fun seekers and engaging in gangsterism during Christmas celebrations.

On the 25th of December 2024, at about 1am, the police operatives attached to Lagos State Command, received a distress call that a group of hoodlums armed with dangerous weapons was operating around the Safejo area of Amukoko, Lagos State. The swift response by the police operatives to the scene led to the arrest of 3 of the suspected hoodlums identified as Emmanuel Okoli ‘m’, 20 years, Ogunde Tejiri ‘m’, 20 years, and Emmanuel Orji ‘m’, 18 years, and also the recovery of the weapons they had used in carrying out robbery attacks on innocent funseekers in the area. The police have emplaced intensified searches to apprehend the fleeing members of the gang.

In a similar development, Police Operatives attached to Saminaka Division of the Kaduna State Command on 25th December 2024, at about 8pm, successfully apprehended one Sule Muhammad ‘m’, 25 years, who has been actively involved in multiple kidnapping incidents within the Saminaka area. Further investigation led to the recovery of a fabricated AK-47 rifle from the suspect. The suspect confessed to being a member of a notorious kidnapping gang who had been evading arrest since the arrest of other gang members on August 16, 2024, until his recent arrest on 25th December 2024. Following cooperation received from Muhammad, efforts are in top gear to apprehend other members of his gang and recover more arms and ammunition in their identified camp. Commendable efforts of the Nigeria Police Operatives have also been witnessed in states including Delta, Ogun Katsina, Benue, FCT and Imo, leading to the arrests of several suspects in various locations during the Christmas celebration period.

The IGP has commended the officers involved in these operations for their vigilance and commitment to public safety, highlighting their display of exemplary dedication in safeguarding our communities, especially during this joyful season. The IGP urges the public to remain vigilant and report any suspicious activities to the authorities.

The IGP further assures citizens that the Force is fully committed to creating a safe environment for everyone as they partake in the joy and cheer of the holiday season. As the celebrations continue, the Nigeria Police Force remains steadfast in its mission to protect all citizens and ensure that the spirit of festivities during this period remains unmarred by criminal activities.

 

ACP OLUMUYIWA ADEJOBI, mnipr, mipra, fCAI,

FORCE PUBLIC RELATIONS OFFICER

FORCE HEADQUARTERS,

ABUJA.

27TH DECEMBER 2024.

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