Connect with us

/">

BIG STORY

Gene Causing Breast Cancer In Nigerian Women Identified

Gbemileke Ajayi

Published

on

A multinational research team has identified the genes responsible for inherited breast cancer in Nigerian women, according to the study published in the August 21, 2018 issue of the Journal for Clinical Oncology.

“This is the first study to use high-throughput genomic analysis of African women,” said study author Olufunmilayo Olopade, MD, Walter L. Palmer, Distinguished Service Professor of Medicine and Human Genetics and Director of the Center for Clinical Cancer Genetics and Associate Dean for Global Health at the University of Chicago.

“Based on state-of-the-art genomic technologies, two things were clear,” added co-author Mary-Claire King, PhD, American Cancer Society Professor of Medicine and Genome Sciences at the University of Washington in Seattle. “Risks to Nigerian women who carry mutations in breast cancer genes are higher than risks to women in the U.S. with mutations in the same genes. And inherited breast cancer plays a bigger role in the total occurrence of breast cancer in Nigeria compared to the U.S.”

According to a report by www.news-medical.net, the study enrolled 1,136 women with invasive breast cancer and 997 controls, women of similar ages and heritage who did not have breast cancer.

The disease was far more advanced at diagnosis than in the US, with 86 per cent of the patients who were fully evaluated diagnosed at either stage 3 or stage 4.

Almost half (46 per cent) of the patients were diagnosed with triple-negative breast cancer (tumours that lack estrogen receptors, progesterone receptors and human epidermal growth factor receptors).

This is an aggressive breast cancer subtype, likely to have a poor prognosis, even in wealthy countries.

For their study of “Inherited Breast Cancer in Nigerian Women,” the authors sequenced 25 genes associated with increased risk of breast cancer and identified all damaging mutations in each of those genes.

They found that one out of eight breast cancers in the study was caused by an inherited mutation in one of four of these genes.

Mutations in BRCA1 (7 per cent of patients) and BRCA2 (4 per cent) were the most common, followed by PALB2 (1 per cent) and TP53 (0.4 per cent).

Patients with BRCA1 or TP53 mutations were diagnosed at younger ages than women with other mutations.

The mean age at diagnosis for all cases in the study was 47.5 years, but the BRCA1 carriers were diagnosed at an average age of 42.6 years.

Patients with TP53 mutations were diagnosed even earlier, at an average age of 32.8 years.

“Genomic sequencing to identify women at extremely high risk of breast cancer could be a highly innovative approach to tailored risk management and life-saving interventions,” the authors wrote. Given the limited treatment resources available in this setting, “prevention and early detection services should target these highest-risk women.”

Following up on the study, the Chicago-Ibadan team has already developed a risk-prediction model for breast cancer in Nigeria and other Sub-Saharan African women, who are, on average, more than 10 years younger when diagnosed than American women.

This predictive model can identify individuals at high risk of breast cancer, tailor surveillance and suggest risk-reduction strategies.

There is an urgent need to address “widening global disparities in breast cancer mortality that disproportionately impact women of African ancestry,” the authors wrote.

Breast cancer among both African American and Nigerian women is more frequently triple-negative than in other populations for complex reasons that remain poorly understood.

Given the young ages at diagnosis in Nigeria, focusing on genetically high-risk women could, the authors suggest “substantially reduce premature mortality from breast cancer.”

“It may seem paradoxical to apply the most recent technology in severely resource-limited settings,” the authors add, “but in fact, the solution fits the problem… Women with an extremely high risk of breast cancer due to mutations in these genes can be identified inexpensively and unambiguously, and offered interventions to reduce cancer risk.”

“Coordinating our team of clinicians and scientists and community elders in Nigeria was no small feat, but we got the job done despite resource constraints,” said Adeyinka Falusi, PhD Professor of Hematology and L’OREAL/UNESCO Laureate, Institute for Advanced Medical Research and Training in the College of Medicine, University of Ibadan.

“As the premier institution in Nigeria, the University of Ibadan remains committed to deploying science and technology to improve the health of Africans on the continent and throughout the diaspora,” Falusi said. “Lessons learned in Nigeria can be transferred back to low resource settings in the US and other countries.

African and African American women are more likely than women of other ancestries to develop and to die from triple-negative breast cancer.

The Nigerian Breast Cancer Study, based in Ibadan, South West Nigeria, has been in the field for more than 20 years.

During this period, breast cancer incidence throughout the country has steadily increased.

BIG STORY

Dawn Of A New Era In Iru Kingdom, The Earlier Adesegun Abiodun-Oniru Realizes This, The Better — Tunde Ishola

Peter Okunoren

Published

on

People fight realities in different ways but for Adesegun Abiodun-Oniru, the Aremo of the past Oniru of Iru Kingdom, it appears the reality is just settling in that not only is he no longer the Aremo to the throne, but the fact that he isn’t the man chosen for the throne is just beginning to become a reality he is being confronted with.

During the reign of their father, the immediate past Oniru, Adesegun, and his siblings and friends lived like kings, they lived it to the very hilt, a life of opulence and royalty, with undisguised disdain for the indigenes and residents of the kingdom.

Even the other princes and princesses of the other royal families were seen as lesser being to the sons and daughters of the then reigning king, this particular perception of the other princes may just be the reason Prince Tijani Oniru could raise his hands to slap a prince on official duties from the palace, Prince Murisiku Ajasa. The face-off between Prince Murisiku and Prince Tijani Oniru ultimately led to the invasion of the palace Sunday, July 5, 2020.

It is important to note that the faceoff yesterday between a prince of the Iru royal family of the Akiogun branch, Prince Tijani Oniru and some members of the enumeration committee led by Prince Murisiku Ajasa on the duty of enumerating the properties of the kingdom on the instruction of the new Oniru, His Royal Majesty, Oba Abdulwasiu Gbolahan Lawal is rather unfortunate.

As a father to all, the doors to the palace is open to all, especially to the princes and princesses of the kingdom, and should they have any grievance on any ongoing project, they ought to approach the palace and seek clarification, rather than engage the committee members who were carrying out their duties.

While there may have been a misunderstanding between Prince Tijani Abiodun-Oniru and Prince Murisiku Ajasa and the committee members, in the course of carrying out their duties, it is expected that as a prince of the royal Iru family, Prince Tijani ought to have handled the situation better and not resort to physically engaging his fellow prince and the committee.

Invading the palace in the company of policemen is an action unbecoming of princes of the kingdom but it can be understood that it may be actions taken in the spur of the moment, but speak very poorly of them. Oba Abdulwasiu Gbolahan Lawal has maintained an open-door policy since ascending the throne and enjoys a very cordial relationship with all the princes of the land.

Adesegun Abiodun-Oniru should have put a call through to Kabiyesi and make his grievances known, rather than invade the palace with his brother and policemen.

As a former law enforcement officer and a well-read and traveled individual, Kabiyesi Abdulwasiu Gbolahan Lawal abhors violence and will never subscribe to the use of brute force or thugs in carrying out any of his plans for Iru kingdom, rather engagement and dialogues have been the route of choice since his ascension.

The ongoing enumeration exercise being carried out by the new Oniru is for the benefit of all the three branches of the royal families, i.e the Akiogun, Abisogun, and Ogunyemi families. In collaboration with consultants, the palace is working assiduously to collate information and create a database of all assets, information, and properties of the kingdom for records of the Oniru Royal Family. There are no malevolent intentions to the project whatsoever as far as we have seen.

The Oniru as the custodian of the heritage, values, and assets of the kingdom knows that proper documentation of everything being held in trust by the throne will go a long way in creating accountability and equity within the kingdom, for generations unborn.

As a father to all, Kabiyesi Gbolahan Lawal has reiterated that peaceful coexistence between all and sundry within the kingdom is his number one priority, as well as redeveloping and rebranding the kingdom for the benefit of the indigenes, residents, and businesses within the kingdom.

The sons of the former Oniru should accord the new custodian of their heritage the deserved respect and should conduct themselves in manners consistent with royal upbringing. The Hausas have an adage, ‘seriki goma, sanmoni goma’ which translates to 10 kings and 10 reigns. It is the reign of a new king and the early they embrace the realities, the better.

 

Tunde Ishola writes from Lagos and he’s also an indigene of Iru Kingdom

Continue Reading

BIG STORY

BREAKING: We Didn’t Arrest Magu, He Was Only Summoned Over Alleged Corruption Cases — DSS

Avatar

Published

on

The Department for State Security (DSS) on Monday denied media reports of the arrest of acting Economic Financial and Crimes Commission (EFCC), Ibrahim Magu.

The security agency said Magu was merely summoned by the presidential panel over alleged corruption cases.

Details shortly…

Continue Reading

BIG STORY

Lagos Traffic May Worsen As FG Plans To Shut Third Mainland Bridge From July 24 For 6 Months To Resume Renovation

Avatar

Published

on

The already bad traffic situation in Lagos, Nigeria’s commercial city, may get worse, as the Federal Government is set to shut down the popular Third Mainland Bridge, from July 24, for six months.

Olukayode Popoola, the Federal Controller of Works in Lagos, disclosed this on Monday, July 6, 2020.

According to Popoola, “We want to do maintenance work on Third Mainland Bridge very soon. Most likely on the 24th. We may close it from the 24th of July.’’

“We are still working out the modalities and when we perfect the traffic management plan we will move to site. Everything being expected for the repairs of the bridge arrived the country that is why we want to start the repairs now,’’

The 11.8km bridge is one of the major links between the Lagos Mainland and Lagos Island, and perhaps, takes heavier traffic than the rest of the bridges, which include Carter Bridge and Eko Bridges.

Its partial or full closure means more traffic will now flow to Carter and Eko Bridges. Incidentally, part of the Eko Bridge, from the Alaka end of the Funsho Williams Avenue had been closed to traffic for some months now.

Popoola said that the planned shut down is to enable the Federal Government to carry out maintenance work from July 24, 2020.

According to him, consultations are ongoing towards developing a perfect traffic management architecture that will be very efficient and effective.

There have been reports of some worn-out joints of the bridge, which raised some safety concerns for the users of the bridge. The Federal Government will be working with the Lagos State Traffic Management Agency (LASTMA) on how best traffic during this period.

It was constructed in 1990 and was the longest in Africa until 1996 when the 6th October Bridge in Cairo, Egypt, was completed.

Continue Reading




JoIn Us On Facebook


Live COVID-19 statistics for
World
Confirmed
11,448,925
Recovered
6,178,355
Deaths
534,254
Last updated: 5 minutes ago






Most Popular

COVID-19 LIVE UPDATE

BE SAFE, STAY AT HOME