Connect with us

NEWS

GOODNEWS: New HIV Drug Eliminates 99% Of Virus Within Four Weeks — Israeli Coy

Gbemileke Ajayi

Published

on

Zion Medical, an Israeli biotech company developing HIV and cancer treatments, has announced the results of the first clinical trial of HIV-drug Gammora, eliminating up to 99 percent of the HIV virus within four weeks of treatment.

Investigational Medicinal Product Gammora is a synthetic peptide compound derived from the HIV enzyme integrase, which is responsible for inserting the virus’s genetic material into the DNA of the infected cell.

Gammora stimulates the integration of multiple HIV DNA fragments into the host cell’s genomic DNA, to an extent that triggers the self-destruction of the infected cell, called apoptosis.

The peptide, produced by San Diego, California-based PolyPeptide Labs, has the potential to cure HIV infected patients, by destroying all cells carrying the HIV virus-genome.

This is opposed to the commercially available retroviral treatments, the so-called “cocktail,” which merely suppresses the spreading of the virus, but do not cure the infection.

Between July and August 2018, Zion Medical conducted a Phase 1/2a human clinical trial of Gammora, reaffirming results of prior preclinical tests that had shown the safety and effectiveness of the drug in killing HIV-infected cells.

In the Part I of this trial, nine HIV-infected patients at the Dr. Ronald Bata Memorial Hospital in Entebbe, Uganda, were randomly assigned to receive either 0.05-0.2 mg/kg, or 0.1- 0.3 mg/kg, or 0.2-0.4 mg/kg of Gammora for up to four weeks to five weeks.

Most patients showed a significant reduction of the viral load of up to 90 percent from the baseline during the first four weeks.

In Part II of the study, conducted two weeks after the first, patients were given Gammora with additional retroviral treatment combined for another four weeks to five weeks.

Patients received either commercially available lopinavir 800 mg and ritonavir 200 mg (LPV+r) daily in combination with Gammora 0.2-0.4 mg/kg given twice a week, or LPV+r only.

The results found that combined-treated patients demonstrated sustained viral suppression and achieved HIV-1 RNA <300 copies/mL, and showed up to 99 per cent reduction in viral load from baseline within four weeks.

Through the 10 weeks, patients in both studies demonstrated that Gammora is a safe and well-tolerable drug, exhibiting no side effects.

Patients showed a significant increase of the CD4 cell count – up to 97 percent from the baseline.

CD4 cells, also referred to T cells or T helper cells, play an important role in the body’s immune system and are an indicator of its overall health.

“These first clinical results were beyond our expectations and promise hope in finding a cure for a disease that’s been discovered over 35 years,” says Dr. Esmira Naftali, head of development at Zion Medical. “Given the limited nature of this study, we are excited to prove the efficiency of our drug in Phase 2b with a greater number of participants over a longer period of time.”

Abraham Loyter, professor at the Hebrew University of Jerusalem, first started research on this novelty drug about 10 years ago, having been granted patents for the peptide in 2015 and 2017 (U.S. Patent No. 9163067, 9738878).

Zion Medical in-licensed the compound and has been continuing research and development through pre-clinical and clinical stages, building an entire team of researchers around the development of Gammora.

On August 31, 2018, Zion Medical filed another patent application with the US Patent and Trademark Office for an updated version of the peptide and final drug composition.

New York City’s Mount Sinai Hospital has collaborated with Zion in earlier stages of development and might partner with the company again in the future.

The company hopes to start Phase 2b in the coming months, involving around 50 patients that are given Gammora over two to three months.

Israel-based Zion Medical was established in 2014 with the mission to develop groundbreaking medical solutions for HIV/AIDS and cancer.

It is known for its patented synthetic peptide Gammora, which is derived from the HIV enzyme integrase and has been proven to be effective in killing HIV-infected cells, and which has also shown promising results with some types of cancers cells.

PR Newswire.

Advertisement
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

NEWS

STOP PRESS! Before We Crucify VP Osinbajo

Gbemileke Ajayi

Published

on

Hysteria is in the DNA of many Nigerians, especially those who are, for parochial or partisan reasons, decidedly and desperately against the administration of President Muhammadu Buhari.

Since the president announced the dissolution of the Economic Management Team headed by Vice President Yemi Osinbajo, SAN, and replaced it with an Economic Advisory Council, there has been mass hysteria in the traditional and new media.

This is apparent in the deluge of dilettante opinion articles, editorials, blog posts, blurbs, and tweets all alluding to the fact that the VP has been politically emasculated by a phantom ‘cabal’ in the presidency because of his growing popularity and influence and the need to whittle them down before 2023.

Some even said he has been marked for impeachment on trumped-up charges that could only have been products of a puerile imagination.

What the President simply did was to change the economic direction of his Next Level agenda; not ‘reduce’, as some also implied, the statutory functions of his beloved VP.

As the chairman of the constitutionally created the National Economic Council, the VP will continue to play a pivotal role in all economic matters in singular support and assistance of his Principal, Mr. President.

For emphasis, the NEC meeting, held monthly, deliberates on the coordination of the economic planning efforts and economic programmes of the various levels of government.

The council comprises the 36 state governors, Governor of the Central Bank of Nigeria, Minister of Finance, Secretary to the Government of the Federation and other government officials and agencies whose duties hinge on the economy.

Last Thursday, the VP still chaired the NEC at the Presidential Villa.

Osinbajo told attendees at the NEC meeting that both councils (NEC and EAC) are for the benefit of the president; and, “If NEC wants to be briefed regularly by the Economic Advisory Council, EAC, we will request the president to do that.” So, nothing has changed, except for the new song by dissidents.

What further sent the rumour mill into overdrive was an alleged directive that the Vice-President should, henceforth, seek presidential approvals for agencies under his supervision.

VP Osinbajo is the chairman of the governing boards of the National Emergency Management Agency (NEMA), the National Boundary Commission (NBC) and the Border Communities Development Agency (BCDA).

He is also the chairman of the board of directors of the Niger Delta Power Holding Company (NDPHC), a limited liability company owned by the three tiers of government; and the National Economic Council (NEC), a constitutional body made up of state governors and key federal government officials, as well as the National Council on Privatisation (NCP).

Under the laws setting up the agencies, the president is empowered to give final approvals but those who chose to ignore this constitutional provision went to town, gloating and ululating, that the VP has eventually been cut to size.

A careful introspection is critical here. Apart from the fact that he is a Senior Advocate of Nigeria, the Vice President, as the whole world knows, is a Professor of Law. So, if anybody should know what the constitution stipulates as the roles and powers of a VP, it is Osinbajo.

So, why would he want to overreach himself knowing what the constitution states? At what point does doing the right thing require a directive? Some things just don’t add up in the name of playing politics.

Late 2018, the House of Representatives Committee on Emergency and Disaster Preparedness invited the VP to explain his role in the N5.8 billion North East Intervention Fund which the lawmakers said was mismanaged by the National Emergency Management Agency (NEMA).

The NEMA is one of the agencies under the VP. The committee said the authorisation for the release of the fund for emergency food intervention in the North East contravened Section 80(4) of the 1999 Constitution as amended. And that the funds were credited directly to the individual banks of the companies and NEMA’s bank account, in violation of the approval limit allowed by law.

Nowhere in the report was the VP alleged to have benefitted from the fund. Good enough, the Presidency issued a public statement to say that the money Osinbajo, in his capacity as the Acting President, approved for release in the dire emergency was sourced from the Rice Levy which had already been appropriated in that year’s budget. And that explanation settled the matter.

However, in the desperation of the strident opposition, the allegation, which had since been dispelled by the House Committee, is now being unearthed as if it were new, in a mere political contrivance intended to distract the President Buhari-led administration.

Every discerning mind should be above this outright fake news and sheer inanity. Just as they should about rumours that some unspecified amount of money was found in some private accounts related to the VP’s family or that some Federal Inland Revenue Services, FIRS, funds were traced to his office. The purveyors of this particular rumour even said that the National Leader of the All Progressives’ Congress, APC, Asiwaju Bola Ahmed Tinubu and a former National Chairman of the party, Chief BisiAkande, had been duly informed. Another such report maintained that Asiwaju himself is behind the attempt to smear the VP.

These are mere fabrications intended to drive a wedge between the VP and those he holds in very high esteem. Thankfully, the president and the party leaders are above such frivolous distractions.

Indeed, at no time since Nigeria’s democratic experience began that the President and his VP have enjoyed the kind of cordial relationship and mutual respect that exists between President Buhari and VP Osinbajo.

The president believes so much in the competence, character, and capacity of his VP that he allows him to handle some of the populist programmes of the administration. And, this has not been without politically-motivated hiccups.

The VP is the ‘face’ of TraderMoni, the empowerment scheme of the Federal Government created specifically for petty traders and artisans across Nigeria. The launch of the scheme saw the VP crisscrossing the country, enlightening the people about it and generally pressing the flesh to the delight of Nigerians. Yet, those who do not know the workings of the scheme have gone to town, falsely accusing the VP of mismanaging the Tradermoni Funds.

Instructively, the Bank of Industry is in charge of the Tradermoni; the funds never get into the hands of the VP or his aides; the money is sent to the people via their phones. The VP has just been monitoring to make sure people received what they were promised and the program was working. So any imputation of embezzlement is nothing but a frantic attempt to soil a hard-earned reputation of loyalty, integrity, and capability which the VP has built in the last four years, and which has helped to steady the incumbent administration in no small measure.

Conclusively, the news and noise of a rift or whittling down of the VP’s powers is akin to a storm in a teacup; both the president and the Vice President are still working in tandem to ensure that Nigerians are genuinely taken to the Next Level in their own time.

Abdullai Rimi, is an Abuja-based media practitioner and businessman

Continue Reading

NEWS

Rotary Club Of Ikeja South Partners Old English, IDCL On Polio Eradication [PHOTOS]

Gbemileke Ajayi

Published

on

As part of efforts to contribute to the global effort of polio eradication, the Rotary Club of Ikeja South has collaborated with Old English Superstores and Indoor Design Concepts Limited.

The partnership was announced during a ceremony where End Polio donation boxes were launched at Old English Superstores, GRA, Ikeja.

In his welcome address, President, Rotary Club of Ikeja of Ikeja South, Rtn Michael Effiong James told members and the general public that the End Polio Project is a battle that must be won, noting that as far as there is still one case of polio in the world, then the disease is still a major threat.

According to him, the desire to end polio forever prompted the club to team up with Old English Superstores and IDCL to raise funds to support the work being carried out by Rotary International in Nigeria, Pakistan, and Afghanistan.

Rtn James revealed that while Old English Superstores has offered its facilities in GRA, Ikeja, Omole Phase 1 and Isolo, IDCL has agreed to design and produce the boxes and create branding materials to promote the initiative.

He thanked the two organizations and called on other corporate organizations to deploy their CSR budgets to worthy causes like this.

In his remarks, special guest at the gathering and District Governor, Rotary International District 9110, Rtn Jide Akeredolu applauded the initiative of making end polio donations boxes available for all to contribute to the End Polio campaign.

He went down memory lane, giving a vivid description of how Rotary International has worked since 1985 when there were 350,000 cases of polio worldwide to today where only a few cases of the wild poliovirus are found in Afghanistan and Pakistan.

“A few weeks ago, we celebrated freedom from the wild poliovirus in Nigeria but we must not lose our guard. The work goes on. We should remain vigilant and keep the advocacy on so that the government and all stakeholders will be on their toes,” Rtn. Akeredolu said.

He also tasked non-Rotarians to key into the project, saying that though a lot has been done, a lot more needs to be done to kick polio out of planet earth forever.

Continue Reading

NEWS

Drunk Policeman Stabs Nine In Akure Nightclub

Gbemileke Ajayi

Published

on

A policeman identified as Sergeant Taiwo Orisadare has allegedly stabbed nine persons at a popular nightclub in Akure, the Ondo State capital.

Trouble started at the nightclub, which is located in Alagbaka GRA area of Akure over the weekend when the policeman attached to the Akure Area Commander’s office allegedly began to behave in an erratic manner.

According to eyewitnesses, the drunk policeman became unruly and started harassing the victims who had come to unwind at the club.

One of the eyewitnesses, who narrated the incident, stated that “It was so clear that he (Sergeant Orisadare) was so drunk and was already becoming something else at the club.

“He won’t just listen to those trying to tell him to take things easy. Things went awry as he started attacking everyone he could lay hands on.

“He stabbed nine people before he could be overpowered.”

Meanwhile, some of the victims, who were attacked by the police officer, are currently recuperating in various hospitals, while some are in critical condition.

The Police Public Relations Officers of the state command, Femi Joseph stated that both parties were engaged in a brawl.

“They were both fighting. The policeman did not stab anyone to death. Do you even know the condition of the policeman now?” He asked.

Continue Reading

Most Popular