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GOODNEWS: New HIV Drug Eliminates 99% Of Virus Within Four Weeks — Israeli Coy

Gbemileke Ajayi

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Zion Medical, an Israeli biotech company developing HIV and cancer treatments, has announced the results of the first clinical trial of HIV-drug Gammora, eliminating up to 99 percent of the HIV virus within four weeks of treatment.

Investigational Medicinal Product Gammora is a synthetic peptide compound derived from the HIV enzyme integrase, which is responsible for inserting the virus’s genetic material into the DNA of the infected cell.

Gammora stimulates the integration of multiple HIV DNA fragments into the host cell’s genomic DNA, to an extent that triggers the self-destruction of the infected cell, called apoptosis.

The peptide, produced by San Diego, California-based PolyPeptide Labs, has the potential to cure HIV infected patients, by destroying all cells carrying the HIV virus-genome.

This is opposed to the commercially available retroviral treatments, the so-called “cocktail,” which merely suppresses the spreading of the virus, but do not cure the infection.

Between July and August 2018, Zion Medical conducted a Phase 1/2a human clinical trial of Gammora, reaffirming results of prior preclinical tests that had shown the safety and effectiveness of the drug in killing HIV-infected cells.

In the Part I of this trial, nine HIV-infected patients at the Dr. Ronald Bata Memorial Hospital in Entebbe, Uganda, were randomly assigned to receive either 0.05-0.2 mg/kg, or 0.1- 0.3 mg/kg, or 0.2-0.4 mg/kg of Gammora for up to four weeks to five weeks.

Most patients showed a significant reduction of the viral load of up to 90 percent from the baseline during the first four weeks.

In Part II of the study, conducted two weeks after the first, patients were given Gammora with additional retroviral treatment combined for another four weeks to five weeks.

Patients received either commercially available lopinavir 800 mg and ritonavir 200 mg (LPV+r) daily in combination with Gammora 0.2-0.4 mg/kg given twice a week, or LPV+r only.

The results found that combined-treated patients demonstrated sustained viral suppression and achieved HIV-1 RNA <300 copies/mL, and showed up to 99 per cent reduction in viral load from baseline within four weeks.

Through the 10 weeks, patients in both studies demonstrated that Gammora is a safe and well-tolerable drug, exhibiting no side effects.

Patients showed a significant increase of the CD4 cell count – up to 97 percent from the baseline.

CD4 cells, also referred to T cells or T helper cells, play an important role in the body’s immune system and are an indicator of its overall health.

“These first clinical results were beyond our expectations and promise hope in finding a cure for a disease that’s been discovered over 35 years,” says Dr. Esmira Naftali, head of development at Zion Medical. “Given the limited nature of this study, we are excited to prove the efficiency of our drug in Phase 2b with a greater number of participants over a longer period of time.”

Abraham Loyter, professor at the Hebrew University of Jerusalem, first started research on this novelty drug about 10 years ago, having been granted patents for the peptide in 2015 and 2017 (U.S. Patent No. 9163067, 9738878).

Zion Medical in-licensed the compound and has been continuing research and development through pre-clinical and clinical stages, building an entire team of researchers around the development of Gammora.

On August 31, 2018, Zion Medical filed another patent application with the US Patent and Trademark Office for an updated version of the peptide and final drug composition.

New York City’s Mount Sinai Hospital has collaborated with Zion in earlier stages of development and might partner with the company again in the future.

The company hopes to start Phase 2b in the coming months, involving around 50 patients that are given Gammora over two to three months.

Israel-based Zion Medical was established in 2014 with the mission to develop groundbreaking medical solutions for HIV/AIDS and cancer.

It is known for its patented synthetic peptide Gammora, which is derived from the HIV enzyme integrase and has been proven to be effective in killing HIV-infected cells, and which has also shown promising results with some types of cancers cells.

PR Newswire.

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Olatoye Sugar’s Family Sues UCH N200m For Releasing Horrific Photo Lawmaker [PHOTO]

Peter Okunoren

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For releasing the photograph, the Olatoye family is seeking N200 million damages.

C. C. Amedu of Ikeh Sunday Chambers in Ibadan filed the petition on behalf of the Olatoye family, which is accusing the hospital of allowing the gory photographs of the late lawmaker in his dying hours at the Intensive Care Unit of the hospital to be circulated on social media, thereby causing members of his family a lot of grief.

The petition was also sent to the Minister of Health, Prof. Isaac Adewole, and the Ibadan chapter of the Nigerian Medical Association.

It reads in part: “A cursory assessment of the attached photographs revealed that the deceased, as at the time the photographs were taken, was still at the Intensive Care Unit of the hospital in a pool of blood. Therefore, it is reasonable and unarguable to believe that only your staff could access the unit at the material time.

“The above conduct of your staff suggested that instead of your personnel on duty to have acted in their full professional capacity, focusing on taking care of the deceased, which might have probably saved his life, they were busy taking his pictures, which perhaps for the purpose of selling same to social media operators as it can be seen trending online.”

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Ganduje Issues Strong Warning Ahead Of Kano Election Rerun

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Ahead of the supplementary elections in Kano on Saturday, Governor Abdullahi Ganduje, has warned that his government will not tolerate any breach of peace by any group or persons in the state.‎

‎Ganduje gave the warning on Tuesday in Kano, when an amalgam of 320 associations called Kano Peace Ambassadors, paid him a solidarity visit.‎

“We will not tolerate breach of peace under whatever guise, and the government will not fold its arms and watch people instigating instability in the state.‎

“As a governor of Kano state and the Chief Security Officer of the state, I cannot sleep if any drop of blood is wasted.

‎”I am not speaking as a gubernatorial candidate, but as the executive governor of Kano state and the chief security officer of the state. Anybody wishing to disrupt the peace of the state will not go scot-free,” he said.‎

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Drama In Kano As Ganduje’s Aide Resigns Over Governor’s Refusal To Concede Defeat In Kano Guber Race

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Alhaji Hashim Suleiman, the Senior Special Assistant on Urban Beautification to Governor Abdullahi Umar Ganduje, has tendered his letter of resignation to Secretary to the State Government.

In his resignation letter, he attributed his reason to the failure of Governor Ganduje to concede defeat to the Guber candidate of the Peoples Democratic Party (PDP), Engineer Abba Kabir Yusuf, who won the election that has been declared inconclusive in controversial circumstances by the Independent National Electoral Commission (INEC).

The letter of resignation, dated, Wednesday, March 13, 2019, which he personally signed, reads, ”I write to formally inform you of my voluntary resignation from the office of SSA, Beautification.

“I thank you for offering me the opportunity to serve under your administration as SSA.”

He added that as a transparent Khadimul-Islam, the governor ought to have conceded defeat, so as to serve as a precedent to other Muslims, who serve Allah in truth and sincerity.

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